C57BL/6-Dll4tm3(DLL4)Bcgen/Bcgen • 112067
| Product name | B-hDLL4 mice |
|---|---|
| Catalog number | 112067 |
| Strain name | C57BL/6-Dll4tm3(DLL4)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| Aliases | DLL4, AOS6, delta4, hdelta2, delta like canonical Notch ligand 4 |
Targeting strategyGene targeting strategy for B-hDLL4 mice. The exons 2-9 of mouse Dll4 gene that encode the extracellular domain were replaced by human DLL4 exons 2-9 in B-hDLL4 mice.
mRNA expression analysis
Strain specific analysis of DLL4 gene expression in wild-type (WT) mice and B-hDLL4 mice by RT-PCR. Mouse Dll4 mRNA was detectable only in heart and lung of WT mice (+/+). Human DLL4 mRNA was detectable only in homozygous B-hDLL4 mice (H/H) but not in WT mice (+/+).
