RenLite mice have full human antibody heavy chain variable regions and a common light chain human variable region for the discovery of fully human bsAb/bsADC antibodies.
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Heavy chain IGHV germline usage of naive RenLite mice
Heavy chain IGHV germline usage of naive RenLite mice
Heavy chain IGHD germline usage of naive RenLite mice
Heavy chain IGHJ germline usage of naive RenLite mice
The median length of heavy chain CDR3 (14aa) from naive RenLite mice is comparable to the average length of human CDR3.
Human-like CDR3 features, such as increasing frequency of tyrosine usage, are observed in RenLite mouse heavy chain CDR3.
Serum concentrations of IgA, IgM and IgG subtypes of RenLite™ and wild type mice were measured by ELISA. Sera were equally diluted between two groups of mice
