Introduction

Orthotopic models involve the seeding of tumor cell lines or patient-derived cell xenografts into animal models. This strategy allows us to assess tumor development in a relevant environment and evaluate efficacy in a preclinical tumor model that mimics the disease process in humans. With orthotopic models, we can closely monitor and accurately quantify primary tumor growth, metastatic activity, and response to therapy scenarios.

In vivo Optical Imaging Technology

Summary of Orthotopic and Metastasis Models