By Therapeutic Area

Neuroscience

Biocytogen has developed a series of genetically engineered mouse models and neurological disease models, including Alzheimer's Disease (AD) , Aging & Inflammation, Pain and Migraine, Amyotrophic lateral sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), and Autism spectrum disorders (ASD) models. A comprehensive behavioral testing platform has also been established to support preclinical drug development.
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  • Neurological Disease Model Introduction
  • Neuroscience Disease Models
  • Case Studies

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    Neurological Disease Model Introduction
    Central nervous system (CNS)-related diseases encompass a wide range of conditions, including cerebrovascular disorders, neurodegenerative diseases, immune-mediated disorders, and others. In clinical practice, these diseases are also classified based on their anatomical location, such as brain disorders, spinal cord disorders, peripheral nerve disorders, and neuromuscular disorders. In recent years, the incidence of CNS diseases has steadily increased with rising life expectancy, and they are now widely recognized as a major global health concern.
    Animal models are indispensable tools in CNS disease research, given the complexity and heterogeneity of these conditions. They help to investigate the underlying pathological and molecular mechanisms, identify potential biomarkers, evaluate the efficacy of therapeutic interventions, and provide preliminary assessments of the safety and effectiveness of drug candidates in humans.
    Neuroscience Disease Models
    Alzheimer's Disease (AD) Models
    Alzheimer's disease, the most common cause of dementia, is a progressive and irreversible neurodegenerative disorder that gradually impairs cognitive functions such as memory, reasoning, and behavior.
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    Aging & Inflammation Models
    Biocytogen's aged mice and behavioral platform support research related to aging and inflammation.
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    Pain and Migraine Models
    Pain models include acute pain, inflammatory pain, neuropathic pain, migraine models, etc.
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    Amyotrophic lateral sclerosis (ALS) Models
    Biocytogen's animal models and behavioral research platform support studies related to amyotrophic lateral sclerosis (ALS).
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    Duchenne Muscular Dystrophy (DMD) Models
    Biocytogen's animal model and behavioral research platform supports studies related to duchenne muscular dystrophy (DMD).
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    Autism spectrum disorders (ASD) Models
    Biocytogen's animal model and behavioral research platform supports studies related to autism spectrum disorder (ASD).
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    Schizophrenia Models
    Biocytogen's animal model and behavioral research platform supports studies related to Schizophrenia.
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    Behavior Testing Platform in Biocytogen

    Biocytogen's Behavior Testing Platform offers comprehensive in vivo assessments of neurological and psychiatric functions, supporting drug discovery and disease research with advanced behavioral analysis.

    case study 1
    Behavior Testing Platform in Biocytogen

    Biocytogen has built a behavioral testing platform, including exercise and fatigue (rotarod , grip strength, beam balance, etc.), anxiety (open field, elevated maze), cognition (fear conditioning, barnes maze, Y-maze, novel object recognition , etc.), and perception (Vonfrey, hot-cold plates, scratching, etc.) tests, which can support preclinical efficacy studies in the fields of neuroscience and brain science.

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    Product Name Product No. Background Action
    B-Dmd KO(del45-50) mice 113915 C57BL/6JNifdc
    B-Fmr1 KO mice 112852 C57BL/6N
    B-Grn KO mice 112567 C57BL/6N
    B-hAGT/hAPOC3 mice 113578 C57BL/6
    B-hAPOE4 mice 112564 C57BL/6JNifdc
    B-hC1Q mice 111990 C57BL/6
    B-hC5AR1 mice 110078 C57BL/6
    B-hCALCRL mice 110115 C57BL/6
    B-hCD14 mice 111130 C57BL/6N
    B-hCD19 mice 112657 C57BL/6JNifdc
    B-hCD33 mice 110823 C57BL/6
    B-hCD3EDG/hTFR1 mice 113616 C57BL/6
    B-hCD98HC rats 113123 SD
    B-hCD98HC/hEGFR mice 113839 C57BL/6
    B-hCD98HC/hFcRn mice 113778 C57BL/6
    B-hCD98HC/hTAU mice 113289 C57BL/6
    B-hCD98HC/hTAU*P301S mice 113206 C57BL/6
    B-hCGRP mice 110118 C57BL/6N
    B-hCSF3 mice 111899 C57BL/6N
    B-hGDF8 mice 112413 C57BL/6N
    B-hGEP mice 112346 C57BL/6N
    B-hGPR171 mice 112807 C57BL/6N
    B-hGPR35 mice 111171 C57BL/6N
    B-hGRP mice 111902 C57BL/6
    B-hHTR3A mice 112973 C57BL/6JNifdc
    B-hLRP10 mice 111014 C57BL/6N
    B-hMAG mice 111033 C57BL/6N
    B-hMASP2/hTWEAK/hAPRIL mice 113136 C57BL/6
    B-hNRP1 mice 111330 C57BL/6
    B-hNTRK1 mice 110810 C57BL/6
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