Biocytogen has developed a series of genetically engineered mouse models and neurological disease models, including Parkinson's disease, stroke (MCAO), experimental allergic encephalomyelitis (EAE), and pain models. A comprehensive behavioral testing platform has also been established to support preclinical drug development.
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There are many types of central nervous system (CNS)-related diseases, covering cerebrovascular diseases, neurodegenerative diseases, immune diseases and other aspects. In medicine, diseases are also classified according to the location of occurrence, such as brain diseases, spinal cord diseases, peripheral nerve diseases, and neuromuscular diseases. In recent years, the number of CNS cases has gradually increased with the increase in life expectancy, and these diseases have been widely recognized as one of the major health problems worldwide.
Animal models are an indispensable tool in the study of CNS-related diseases due to their significant complexity and heterogeneity, helping to explore underlying pathological and molecular mechanisms, identify possible biomarkers, evaluate the efficacy of treatments and interventions, and provide preliminary assessments of safe and effective dosages of drug candidates in humans.
Biocytogen has developed a series of preclinical animal models of neurological diseases, such as Parkinson's disease, stroke (MCAO), experimental allergic encephalomyelitis (EAE), pain models, etc., and has built a behavioral testing platform, including movement & fatigue, anxiety, cognition, and perception tests, to facilitate preclinical drug development.
B-CAG hSNCA*A53T mice was developed for preclinical Parkinson's disease research.
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The Middle Cerebral Artery Occlusion (MCAO) model is a widely used preclinical tool that replicates ischemic stroke in humans, making it ideal for preclinical studies.
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MOG-induced EAE disease can be used for the efficacy evaluation of MS-related drugs.
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A CFA-induced inflammatory pain model and a B6-F10 cell-induced cancer pain model were established for preclinical efficacy studies.
Learn MoreBiocytogen's Behavior Testing Platform offers comprehensive in vivo assessments of neurological and psychiatric functions, supporting drug discovery and disease research with advanced behavioral analysis.
Biocytogen has built a behavioral testing platform, including exercise and fatigue (rotarod , grip strength, beam balance, etc.), anxiety (open field, elevated maze), cognition (fear conditioning, barnes maze, Y-maze, novel object recognition , etc.), and perception (Vonfrey, hot-cold plates, scratching, etc.) tests, which can support preclinical efficacy studies in the fields of neuroscience and brain science.
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