A global knockout (KO) mouse model is a genetically modified mouse in which a specific gene is inactivated or “knocked out” by introducing a positive selection marker (Neomycin in most cases) to replace or disrupt the existing gene, or using EGE™ method to generate a constitutive knockout. In global KO mice, the gene of interest is disrupted across all tissues.
KO mice have been useful include gene function studies and modeling different kinds of disease (e.g. cancer, obesity, diabetes, aging etc.). Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.
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Since our inception in 2009, our company’s strong focus on genetic engineering has led to the creation of multiple strains of mice for preclinical efficacy testing as well as antibody drug discovery. More recently, our team has been working to create knockout mice for key drug target genes to facilitate mechanistic studies and target discovery. For this purpose, we are pleased to introduce more than 800 new strains of knockout mice, now available to the global biomedical research community.
C57BL/6N-Hbb-bttm1Bcgen Hbb-bstm1Bcgen/Bcgen • 113046
NOD.CB17-Prkdcscid Il2rgtm1Bcgen B2mtm1Bcgen Fcgrttm1(B2m/Fcgrt)Bcgen H2-Ab1tm1Bcgen/Bcgen • 111895
