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Establishment of orthotopic prostate cancer model.
The mouse orthotopic prostate cancer was generated by implanting B-Tg(Luc) LNCap clone FGC cells in the dorsal prostate lobes of B-NDG mice (M, n=7), , and the body weight and tumor volume of the mice were recorded weekly. The results showed that the tumor volume increased and body weight of mice gradually decreased during this study. This indicates that the cell line was successfully constructed as an orthotopic tumor model. H&E staining showed that Necrosis and hemorrhage were seen in prostate tumors, and inflammatory cell infiltration can be seen in seminal vesicles.
Establishment of orthotopic prostate cancer model.
The mouse orthotopic prostate cancer was generated by implanting B-Tg(Luc) PC-3 cells in the dorsal prostate lobes of B-NDG mice (M, n=7), and the body weight and tumor volume of the mice were recorded weekly. The results showed that the tumor volume increased and body weight of mice slightly change during this study. This indicated that the cell line was successfully constructed as an orthotopic tumor model. H&E staining showed that tumor cells were seen in prostate.
