B-hEMP2 mice

C57BL/6-Emp2tm1(EMP2)Bcgen/Bcgen • 111358

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B-hEMP2 mice

Product nameB-hEMP2 mice
Catalog number111358
Strain nameC57BL/6-Emp2tm1(EMP2)Bcgen/Bcgen
Strain backgroundC57BL/6
AliasesEMP2 (XMP)
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hEMP2 mice. The exons 2-5 of mouse Emp2 gene that encodes the full-length protein was replaced by human EMP2 exons 2-5 in B-hEMP2 mice.

      mRNA expression analysis
      Strain specific analysis of EMP2 gene expression in wild-type C57BL/6 mice and B-hEMP2 mice by RT-PCR. Mouse Emp2 mRNA was detectable only in the lung of wild-type C57BL/6 mice (+/+). Human EMP2 mRNA was detectable only in homozygous B-hEMP2 mice (H/H), but not in wild-type mice.