IL26 belongs to the IL10 cytokine family, produced by a variety of cells, such as T cells, NK cells, alveolar macrophages, bronchial epithelial cells and many other cells. Th17 cells are the main source of IL26, and responsible in natural immunity as well as the development of inflammatory diseases. It is possible to directly use the transgenic mice to induce and establish inflammatory models, such as RA and psoriasis, to provide pre-clinical efficacy evaluation.