Strain specific Apo(a) protein expression analysis in B-hLPA mice by ELISA. Serum were collected from homozygous B-hLPA mice (H/H) of both genders (n=3 for each) at various ages. Human Apo(a) was exclusively detectable in these homozygous B-hLPA mice at various ages.

Changes of plasma apo(a) levels in heterozygous B-hLPA mice in response to olpasiran analog. Olpasiran analog (provided by the client) is a double-strand small interfering RNA (siRNA) targeting lipoprotein(a) and potently reduce plasma Lp(a) concentration. As shown in the panel, Olpasiran analog reduced Apo(a) concentrations in heterozygous B-hLPA mice(A), achieving up to over 80% reduction from baseline(B) after administration of a single dose. The mice can be used for preclinical studies of efficacy.