B-hNOTCH1 mice

C57BL/6-Notch1tm1(NOCTH1)Bcgen/Bcgen • 110904

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B-hNOTCH1 mice

Product nameB-hNOTCH1 mice
Catalog number110904
Strain nameC57BL/6-Notch1tm1(NOCTH1)Bcgen/Bcgen
Strain backgroundC57BL/6
AliaseshN1, AOS5, TAN1, AOVD1, ICN1

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  • Phenotypic analysis

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      Protein expression analysis in thymus

      Strain specific NOTCH1 expression analysis in homozygous B-hNOTCH1 mice by flow cytometry. Thymus were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hNOTCH1 mice (H/H), and analyzed by flow cytometry with species-specific anti-NOTCH1 antibody. Mouse NOTCH1 was detectable in wild-type mice. Human NOTCH1 was exclusively detectable in homozygous B-hNOTCH1 mice.

      Protein expression analysis in lung

      Strain specific NOTCH1 expression analysis in homozygous B-hNOTCH1 mice by flow cytometry. Lung were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hNOTCH1 mice (H/H), and analyzed by flow cytometry with species-specific anti-NOTCH1 antibody. Mouse NOTCH1 was not detectable in wild-type mice. Human NOTCH1 was not detectable in homozygous B-hNOTCH1 mice.

      Protein expression analysis in kidney

      Strain specific NOTCH1 expression analysis in homozygous B-hNOTCH1 mice by flow cytometry. Kidney were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hNOTCH1 mice (H/H), and analyzed by flow cytometry with species-specific anti-NOTCH1 antibody. Mouse NOTCH1 was not detectable in wild-type mice. Human NOTCH1 was not detectable in homozygous B-hNOTCH1 mice.