B-NDG hB2M/HLA-A11.1 mice

NOD.CB17-PrkdcscidIl2rgtm1 BcgenB2mtm1(B2M/HLA-A11.1)Bcgen/Bcgen • 112451

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B-NDG hALB/hFcRn mice
B-NDG hB2M/HLA-A11.1 mice plus

B-NDG hB2M/HLA-A11.1 mice

Product nameB-NDG hB2M/HLA-A11.1 mice
Catalog number112451
Strain nameNOD.CB17-PrkdcscidIl2rgtm1 BcgenB2mtm1(B2M/HLA-A11.1)Bcgen/Bcgen
Strain backgroundB-NDG
AliasesB2m: Ly-m11, beta2-m, beta2m; HLA-A: HLAA
ApplicationTo verify the efficacy of HLA-A11.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
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  • Phenotypic analysis

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      Protein expression analysis
      B2M and HLA-A11.1 expression analysis in homozygous B-NDG hB2M/HLA-A11.1 mice by flow cytometry. Splenocytes were collected from B-NDG mice (+/+) and homozygous B-NDG hB2M/HLA-A11.1 mice (H/H), and analyzed by flow cytometry with strain specific antibodies. Mouse B2M was detectable in B-NDG mice but not in B-NDG hB2M/HLA-A11.1 mice. Human B2M and HLA-ABC were exclusively detectable in homozygous B-NDG hB2M/HLA-A11.1 mice but not in B-NDG mice.