B-NDG Hc mice

NOD.CB17-Prkdcscid Il2rgtm1Bcgen Hctm1(c645insTA)Bcgen/Bcgen • 110605

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B-NDG hB2M/HLA-A3.1 mice plus
B-NDG hCSF1 mice

B-NDG Hc mice

Product nameB-NDG Hc mice
Catalog number110605
Strain nameNOD.CB17-Prkdcscid Il2rgtm1Bcgen Hctm1(c645insTA)Bcgen/Bcgen
Strain backgroundB-NDG
Aliases C5, C5a, He, Hfib, Hfib2
ApplicationAntibody CDC function study
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  • Phenotypic analysis

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      Measurement of C5 inSerum
      C5 expression analysis in homozygous B-NDG Hc mice by ELISA. Serum were collected from C57BL/6, B-NDG mice and homozygote B-NDG Hc mice, and analyzed by ELISA with C5 ELISA kit. Mouse C5 was detectable in C57BL/6 mice and B-NDG Hc mice. but not B-NDG mice.
      Measurement of total complement hemolytic activity in serum

      Hemolytic capacity analysis in homozygous B-NDG Hc mice. Representative image demonstrating level of lysis of antibody-coated SRBC following incubation with diluted serum from human, C57BL6, B-NDG, or B-NDG Hc mice. Serum from human were used as positive complement control. Compared with B-NDG, the hemolytic ability of B-NDG Hc was significantly enhanced. The order of hemolytic capacity: B-NDG Hc ≥ C57BL/6 > B-NDG.