B-Alb-iCreERT2 mice

C57BL/6-Col1a1tm1(Alb-icre/ERT2)Bcgen/Bcgen • 110137

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B-Alb-iCreERT2 mice

Product nameB-Alb-iCreERT2 mice
Catalog number110137
Strain nameC57BL/6-Col1a1tm1(Alb-icre/ERT2)Bcgen/Bcgen
Strain backgroundC57BL/6
Official symbolAlb, albumin; Alb1; Alb-1; BCL002
Chromosome11
ApplicationB-Alb-iCreERT2 mice expressing icreERT2 under the control of the Alb promoter allow efficient Tamoxifen-dependent recombination of floxed DNA selectively in hepatocytes.
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  • Phenotypic analysis

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      Description

      Homozygousmiceforthetargetedmutationareviable,fertile,normalinsizeanddonotdisplayanygrossphysicalorbehavioralabnormalities

      Analysis of liver by immunofluorescence(IF).
      Control: without tamoxifen treatment; HNF4α: a regulator of liver-specific gene expression. Immunofluorescence for HNF4α, tdTomato, and DAPI on liver sections shows Alb-iCreERT2(Mut/+), CAG-LSL-tdTomato(Mut/+) mice labeled almost all hepatocytes after tamoxifen treatment.
      Analysis of kidney by immunofluorescence(IF).

      Control: without tamoxifen treatment; HNF4α: a regulator of liver-specific gene expression. Immunofluorescencefor HNF4α, tdTomato, and DAPI on kidney sections shows Alb-iCreERT2(Mut/+), CAG-LSL-tdTomato(Mut/+) mice were not labeled after tamoxifen treatment.