C57BL/6-Htr2ctm1(icre)Bcgen/Bcgen • 110139
| Product name | B-Htr2c-iCre mice |
|---|---|
| Catalog number | 110139 |
| Strain name | C57BL/6-Htr2ctm1(icre)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| Official symbol | Htr2c(5-hydroxytryptamine(serotonin) receptor 2C), SR1; Htr1; 5HT1c |
| Chromosome | X |
| Application | B-Htr2c-iCre mice |
DescriptionTSerotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, modulating serotonergic neurotransmission in the central nervous system. In this strain, codon optimized Cre recombinase expression is under the control of Htr2c promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, iCre-mediated recombination results in deletion of the flanked sequence in Htr2c expressing cells.
Targeting strategyAn P2A-iCre sequence cassette was placed between the coding sequence of exon 6 and 3’UTR of the Htr2c gene. This strain was maintained on a C57BL/6 genetic background.
Phenotype Analysis
Top: a construct was used to generate CaMPARIloxP/loxP mice.Bottom: low-and high-magnifications images show CaMPARI expression in Htr2c cells after crossing CaMPARIloxP/loxP mice with Htr2c-Cre mice.
