The results showed that the body weight of homozygous B-ob/ob mice (-/-) was continuously higher than that of the control group after 4 weeks of age.

The results showed that the body weight of homozygous B-ob/ob mice (-/-) was continuously higher than that of the control group after 4 weeks of age.

Efficacy of the anti-human GCGR antibody drug crotedumab in B-ob/ob mice. (A) Body weight changes in B-ob/ob mice. (B-C) Non-fasting blood glucose and fasting blood glucose measurement. Male B-ob/ob mice, 8-10 weeks old, were randomly assigned to 2 groups of 6-7 animals each. Dosing occurred on Day 0. Non-fasting blood glucose was measured on days 0, 3, and 7, and fasting blood glucose after 6 hours of fasting. (D) Crotedumab improves glucose tolerance. (E) The area under the curve of blood glucose content. Mice were fasted for 6 h under free access to water, fasting blood glucose was measured at the tail tip (0 min), injected intraperitoneally at 2 g/kg, and blood glucose was measured at the indicated times. (Fig. F-G) glucagon and insulin measurements. The results showed that crotedumab had hypoglycemic effects in both fasted and non-fasted states while improving glucose tolerance in B-ob/ob mice. (Fig. Data are mean ± SEM; P ≤ 0.05, P ≤ 0.01, P ≤ 0.001)