B-hAMHR2 mice

C57BL/6N-Amhr2tm1(AMHR2)Bcgen/Bcgen • 111143

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B-hAMHR2 mice

Product nameB-hAMHR2 mice
Catalog number111143
Strain nameC57BL/6N-Amhr2tm1(AMHR2)Bcgen/Bcgen
Strain backgroundC57BL/6N
NCBI gene ID110542
AliasesAMHR2, AMHR, MISR2, MISRII, MRII
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  • Phenotypic analysis
  • Efficacy

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      mRNA expression analysis
      Strain specific analysis of AMHR2 gene expression in wild-type C57BL/6 mice and hAMHR2 mice by RT-PCR. Mouse Amhr2 mRNA was detectable only in ovary of wild-type C57BL/6 mice (+/+). Human AMHR2 mRNA was detectable only in homozygous B-hAMHR2 mice (H/H), but not in wild-type mice.
      Protein expression analysis
      Strain specific analysis of AMHR2 expression in WT and B-hAMHR2 mice by western blot. Lung were collected from WT mice and homozygous B-hAMHR2 (H/H) mice. Mouse AMHR2 was detectable in WT mice. Human Amhr2 was detectable in homozygous B-hAMHR2 mice. The antibody is cross-reactive between human and mouse.
      In vivo efficacy of anti-human AMHR2 antibody

      Antitumor activity of anti-human AMHR2 antibody in B-hAMHR2 mice. (A) Murlentamab (in house) inhibited B-hAMHR2 ID8 tumor growth in B-hAMHR2 mice. B-hAMHR2 ID8 cells were subcutaneously implanted into homozygous B-hAMHR2 mice (female, 6-week-old, n=6). Mice were grouped when tumor volume reached approximately 50-80 mm3, at which time they were treated with murlentamab (in house) in panel A. (B) Body weight changes during treatment. As shown in panel A, murlentamab (in house) was efficacious in controlling tumor growth in B-hAMHR2 mice, demonstrating that the B-hAMHR2 mice provide a powerful preclinical model for in vivo evaluation of anti-human AMHR2 antibody. Values are expressed as mean ± SEM.