B-hCCL11 mice

C57BL/6N-Ccl11tm1(CCL11)Bcgen/Bcgenn • 111404

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B-hCB2 mice
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B-hCCL11 mice

Product nameB-hCCL11 mice
Catalog number111404
Strain nameC57BL/6N-Ccl11tm1(CCL11)Bcgen/Bcgenn
Strain backgroundC57BL/6N
AliasesCCL11(SCYA11)
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hCCL11 mice. The exons 1-3 of mouse Ccl11 gene that encode the full-length protein were replaced by human CCL11 exons 1-3 in B-hCCL11 mice.

      Protein expression analysis
      Strain specific CCL11 expression analysis in homozygous B-hCCL11 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hCCL11 mice (H/H), and analyzed by ELISA with species-specific CCL11 ELISA kit. Mouse CCL11 was detectable only in wild-type mice. Human CCL11 was detectable in homozygous B-hCCL11 mice but not in wild-type mice.