B-hFSTL3 mice

C57BL/6N-Fstl3tm1(FSTL3)/Bcgen • 112348

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B-hFSTL3 mice

Product nameB-hFSTL3 mice
Catalog number112348
Strain nameC57BL/6N-Fstl3tm1(FSTL3)/Bcgen
Strain backgroundC57BL/6N
AliasesFSTL3: FLGR, FSRP
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hFSTL3 mice. The exons 1~3 of mouse Fstl3 gene that encode the full-length protein were replaced by human FSTL3 exons 1~5 in B-hFSTL3 mice.

      Protein expression analysis
      Strain specific FSTL3 expression analysis in homozygous B-hFSTL3 mice by ELISA. Serum collected from wild-type C57BL/6N mice (+/+) and homozygous B-hFSTL3 mice (H/H) were analyzed by ELISA with human-specific FSTL3 ELISA kit. Human FSTL3 was exclusively detectable in homozygous B-hFSTL3 mice but not in wild-type mice.