B-hIFNB1 mice

C57BL/6N-Ifnb1tm1(IFNB1)/Bcgen • 111210

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B-hIFNB1 mice

Product nameB-hIFNB1 mice
Catalog number111210
Strain nameC57BL/6N-Ifnb1tm1(IFNB1)/Bcgen
Strain backgroundC57BL/6N
AliasesIFB; IFF; IFNB; IFN-beta
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hIFNB1 mice. The full coding sequence of mouse Ifnb1 was replaced by human IFNB1 coding sequences in B-hIFNB1 mice, so the mouse Ifnb1 gene was disrupted.

      Protein expression analysis
      Strain specific IFNB1 expression analysis in homozygous B-hIFNB1 mice by ELISA. Serum were collected from wild type (+/+) and homozygous B-hIFNB1 mice (H/H) stimulated with LPS for 2 hours in vivo, and analyzed by ELISA with species-specific IFNB1 ELISA kit. Mouse IFNB1 was detectable in wild type mice. Human IFNB1 was exclusively detectable in homozygous B-hIFNB1 mice but not in wild type mice.