C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen • 121444
| Product name | B-hS100A9/hS100A8 mice |
|---|---|
| Catalog number | 121444 |
| Strain name | C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen |
| Strain background | C57BL/6N |
| Aliases | S100A9: MIF, NIF, P14, CAGB, CFAG, CGLB, L1AG, LIAG, MRP14, 60B8AG, MAC387, S100-A9 S100A8: P8, MIF, NIF, CAGA, CFAG, CGLA, L1Ag, MRP8, CP-10, MA387, 60B8AG, S100-A8 |
Targeting strategyGene targeting strategy for B-hS100A9/hS100A8 mice. The exons 2~3 of mouse S100a9 gene were replaced by human S100A9 exons 2~3 in B-hS100A9/hS00A8 mice. The exons 2~3 of mouse S100a8 gene were replaced by human S100A8 exons 2~3 in B-hS100A9/hS00A8 mice.
Protein expression analysis
Strain specific S100A9/A8 expression analysis in homozygous B-hS100A9/hS100A8 mice by ELISA. Plasma was collected from wild-type mice (+/+) and homozygous B-hS100A9/hS100A8 mice (H/H;H/H), and analyzed by ELISA. Mouse S100A9/A8 was detectable in wild-type mice. Human S100A9/A8 was only detectable in homozygous B-hS100A9/hS100A8 mice.
