B-hTIMP1 mice

C57BL/6N-Timp1tm1(TIMP1)Bcgen/Bcgen • 112339

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B-hTIMP1 mice

Product nameB-hTIMP1 mice
Catalog number112339
Strain nameC57BL/6N-Timp1tm1(TIMP1)Bcgen/Bcgen
Strain backgroundC57BL/6N
AliasesTIMP1(CLGI, EPA, EPO, HCI, TIMP, TIMP-1)
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hTIMP1 mice. The exons 2-6 of mouse Timp1 gene that encode the full-length protein, not including signal peptide were replaced by human TIMP1 exons 2-6 in B-hTIMP1 mice.

      Protein expression analysis
      Strain specific TIMP1 protein expression analysis in homozygous B-hTIMP1 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hTIMP1 mice(H/H), and analyzed by ELISA with species-specific TIMP1 ELISA kit. Mouse TIMP1 was detectable in wild-type mice. Human TIMP1 was exclusively detectable in homozygous B-hTIMP1 mice.