B-FcRn KO mice

C57BL/6N-Fcgrttm1Bcgen/Bcgen • 110165

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B-FcRn KO mice

Product nameB-FcRn KO mice
Catalog number110165
Strain nameC57BL/6N-Fcgrttm1Bcgen/Bcgen
Strain backgroundC57BL/6N
NCBI gene ID14132
AliasesFCGRT(Fc fragment of IgG receptor and transporter)
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-FcRn KO mice. The exons of mouse Fcgrt 1-5 were knocked out in B-FcRn KO mice.

      mRNA expression analysis
      Strain specific analysis of Fcgrt gene expression in C57BL/6(+/+) and B-FcRn KO mice by RT-PCR.Kidney was collected from C57BL/6(+/+) mice and homozygous B-FcRn KO mice. Mouse Fcgrt mRNA was detectable in C57BL/6(+/+) mice but not the homozygous B-FcRn KO mice.
      Protein expression analysis
      Strain specific analysis of FcRn expression in C57BL/6(+/+) and the homozygous B-FcRn KO mice by western blot.Kidney was collected from C57BL/6(+/+) mice and homozygous B-FcRn KO mice. Mouse FcRn was detectable in C57BL/6(+/+) mice but not the homozygous B-FcRn KO mice.
      FcRn-deficient mice have low serum IgG
      Sera from C57BL/6(+/+) mice and B-FcRn KO mice were analyzed by ELISA .