B-hUPAR mice

C57BL/6-Upartm1(UPAR)Bcgen/Bcgen • 111081

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B-hUPAR mice

Product nameB-hUPAR mice
Catalog number111081
Strain nameC57BL/6-Upartm1(UPAR)Bcgen/Bcgen
Strain backgroundC57BL/6
AliasesCD87; UPAR; URKR; U-PAR;PLAUR
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      The part of exon 2 and exons 3-7 of mouse Upar gene sequences were replaced by human UPAR counterpart gene sequences in B-hUPAR mice.

      Protein expression analysis
      UPAR (also named PLAUR) expression analysis in homozygous B-hUPAR mice by flow cytometry. Peritoneal macrophages were collected from wild-type mice (+/+) and homozygous B-hUPAR mice (H/H) stimulated with LPS, and analyzed by flow cytometry with species-specific anti-UPAR antibody. Mouse UPAR was detectable in wild-type mice. Human UPAR was detectable in homozygous B-hUPAR mice.