B-hEPO mice

C57BL/6N-Epotm1(EPO)Bcgen/Bcgen • 112458

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B-hEPHB3 mice
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B-hEPO mice

Product nameB-hEPO mice
Catalog number112458
Strain nameC57BL/6N-Epotm1(EPO)Bcgen/Bcgen
Strain backgroundC57BL/6N
AliasesEPO: EP; DBAL; ECYT5; MVCD2
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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hEPO mice. The exons 1-5 of mouse Epo gene that encodes the full-length protein were replaced by human EPO exons 1-5 in B-hEPO mice.

      Protein expression analysis
      Strain specific EPO expression analysis in homozygous B-hEPO mice by ELISA. Serum were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hEPO mice (H/H) and analyzed by ELISA with species-specific EPO ELISA kit. Mouse EPO was detectable in wild-type mice (A). Human EPO was exclusively detectable in homozygous B-hEPO mice but not in wild-type mice (B).* 1 ng/mL=21.2 miu/L